Download e-book for iPad: Antibody Fc: Chapter 11. Activating and Inhibitory FcγRs in by Falk Nimmerjahn

By Falk Nimmerjahn

ISBN-10: 0123948029

ISBN-13: 9780123948021

Autoimmune issues are characterised by means of the destruction of self-tissues through the immune procedure. a number of checkpoints are in position to avoid autoreactivity lower than common conditions. Co-expression of activating and inhibitory Fc receptors (FcRs) represents one of these checkpoint by means of setting up a threshold for immune cellphone activation. in lots of human autoimmune illnesses, notwithstanding, balanced FcR expression is disturbed. research of murine version structures offers powerful proof that aberrant FcR expression may end up in out of control immune responses and the initiation of autoimmune affliction. This assessment summarizes those information and explains how this data can be used to raised comprehend human autoimmune illnesses and to advance novel healing strategies.

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Antibody Fc: Chapter 11. Activating and Inhibitory FcγRs in Autoimmune Disorders by Falk Nimmerjahn

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